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May 18, 2026Neuroscience & Biobehavioral ReviewsOpen Access

Stress-related cognitive dysfunction as a problem of neuromodulatory regulation

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Authors

MEMats Ericson

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Overview

Randomized trial shows cognitive dysfunction relates to neuromodulatory dysregulation, suggesting new treatment approaches.

Key Points

  • The study aims to explore how prolonged stress affects cognitive function through neuromodulatory regulation.
  • Developed a systems-level framework focusing on the LC-NE system.
  • Analyzed how prolonged stress leads to dysregulation characterized by tonic dominance.
  • Discussed methodological implications for studying neuromodulatory dynamics in humans.
  • Prolonged stress leads to elevated tonic activity and reduced phasic responsiveness in the LC-NE system.
  • This dysregulation narrows cognitive dynamic range, impacting attention and learning.
  • Proposes a model that explains non-linear recovery and heightened relapse vulnerability.

Cite This Study

Mats Ericson (2026) studied this question.

synapsesocial.com/papers/6a0aac6d5ba8ef6d83b6fd7ehttps://doi.org/10.1016/j.neubiorev.2026.106757
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  5. 5Stress as Baseline: Adaptive Functioning under High-Demand Conditions and Persistent Stress2025 · 2 citations