An Examination of Cobalt(II) Porphyrin: Electrochemical Properties, Reduction Characteristics, DFT Calculations, and Molecular Docking With α‐Glucosidase

Electrochemical studies of cobalt(II) meso ‐tetrakis(3,4,5‐trimethoxyphenyl)porphyrin Co II (T(3,4,5‐OCH 3 )PP) were conducted using the cyclic voltammetry technique. UV‐Vis and EPR were used to investigate the reduction properties of Co II (T(3,4,5‐OCH 3 )PP). The CV data show that Co II (T(3,4,5‐OCH 3 )PP) is reduced to Co I (T(3,4,5‐OCH 3 )PP) and then reacts with dichloromethane to form Co III (T(3,4,5‐OCH 3 )PP). This occurs due to electrosynthesis establishing a σ bond between the cobalt atoms and the carbon atoms in the meso position of the porphyrin. UV‐Vis analysis indicates that incorporation of diethylamine and triethylamine facilitates the formation of cobalt(III) and cobalt(I). EPR confirms that Co II (T(3,4,5‐OCH 3 )PP) has changed into a five‐coordinate complex. Furthermore, a computer study of the HOMO–LUMO, MEP, and molecular docking of Co II (T(3,4,5‐OCH 3 )PP) has also been done.