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May 18, 2026BMC Infectious DiseasesOpen Access

Does the severity of neutropenia affect mortality in bacteremic cancer patients?

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Authors

PCPeng-Hao ChangPHPo-Yen HuangSSShian-Sen Shie

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Overview

Retrospective cohort study analyzes neutropenia severity effects on mortality in cancer patients, suggesting manageable risks with antibiotics.

Key Points

  • To determine if the severity of neutropenia impacts 30-day mortality in bacteremic patients with cancer.
  • Retrospective cohort study of adults with neutropenic bacteremia receiving cefepime for over 48 hours
  • Included patients with severe (ANC 100–500 cells/µL) and profound neutropenia (ANC < 100 cells/µL)
  • Used Cox proportional hazards model to identify predictors of mortality.
  • Overall mortality rate was 13.5% in 200 bacteremias
  • No significant mortality difference between profound (20.0%) and severe neutropenia groups (11.3%; P = 0.121)
  • Major mortality predictors included pneumonia (aHR 3.81), higher Pitt scores (aHR 1.26 per point), and Charlson index (aHR 1.27 per point).

Cite This Study

Chang et al. (2026) studied this question.

synapsesocial.com/papers/6a0aacb35ba8ef6d83b7015fhttps://doi.org/10.1186/s12879-026-13574-2
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