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This research aims to develop a sustainable method for synthesizing 1,4-diamides using cobalt catalysis.

May 18, 2026Open Access

Cobalt-catalyzed synthesis of 1,4-diamides from alkynes promoted by light

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Randomized trial demonstrates efficient synthesis of 1,4-diamides from alkynes, highlighting environmentally friendly catalysis.

This research aims to develop a sustainable method for synthesizing 1,4-diamides using cobalt catalysis.
Cobalt-catalyzed double hydroaminocarbonylation of alkynes
Utilized unmodified cobalt carbonyl catalyst under mild conditions
Applied visible light irradiation to promote the reaction.
Successfully synthesized unsymmetric 1,4-diamides with near perfect regioselectivities using different amine nucleophiles.
Displayed broad substrate scope for both alkyne and amine components.

Dylan Hsu (2026) studied this question.

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May 18, 2026Open Access

View Full Paper

Ask AI

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Authors

Randomized trial demonstrates efficient synthesis of 1,4-diamides from alkynes, highlighting environmentally friendly catalysis.

This research aims to develop a sustainable method for synthesizing 1,4-diamides using cobalt catalysis.
Cobalt-catalyzed double hydroaminocarbonylation of alkynes
Utilized unmodified cobalt carbonyl catalyst under mild conditions
Applied visible light irradiation to promote the reaction.
Successfully synthesized unsymmetric 1,4-diamides with near perfect regioselectivities using different amine nucleophiles.
Displayed broad substrate scope for both alkyne and amine components.

Dylan Hsu (2026) studied this question.

View Full Paper

Ask AI

Bookmark