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May 18, 2026Biomaterials Science0 citations

Biomimetic Injectable Methacrylated Chondroitin Sulfate-Collagen Hydrogels Enhance Chondrocyte Function and Promote Osteochondral Regeneration

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YYYining YangYLYanni LiYZYu Zhang

Key Points

  • The aim is to develop biomimetic scaffolds that can effectively promote regeneration of cartilage and subchondral bone.
  • Utilized a type I acid-soluble collagen-based hydrogel.
  • Assessed chondrocyte function in vitro and osteochondral regeneration in vivo.
  • Conducted comparative analyses of cell behavior and tissue responses.
  • Hydrogels enhanced chondrocyte function compared to controls.
  • Significant improvements in cartilage and subchondral bone integration.
  • Demonstrated promising outcomes for overall osteochondral regeneration.

Abstract

The development of biomimetic scaffolds capable of promoting both cartilage and subchondral bone regeneration remains a major challenge in osteochondral tissue engineering. In this study, type I acidsoluble collagen (ASC)...

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Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a0aad015ba8ef6d83b707b2https://doi.org/10.1039/d6bm00316h
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