Microcirculatory effects of cardiopulmonary bypass primings in coronary artery bypass graft surgery the prime randomised clinical trial for a physiological proof-of-principle
Randomized trial examines microcirculatory perfusion in CABG patients using different prime fluids, indicating potential dysfunction.
Key Points
This study investigates how different cardiopulmonary bypass prime fluids affect microcirculatory perfusion during coronary artery bypass graft surgery.
Randomized trial with 34 patients
Patients were given CPB primed with albumin, gelofusine, or ringers plus retrograde autologous priming
Primary outcome measure was perfused vessel density assessed at defined intervals.
All priming strategies impaired perfused vessel density after CPB (albumin/ringers -7.56 [95% CI -11.53 to -3.59] mm.mm-2, gelofusine/ringers -4.10 [95% CI -7.53 to -0.67] mm.mm-2, ringers/RAP -3.77 [95% CI -6.64 to -0.90] mm.mm-2)
No significant differences were found between groups (p = 0.41)
Interleukin-6 and angiopoietin-2 levels increased with albumin/ringers compared to other groups.