Fiedler Inversion Score (FIS) v5: Human Proteome Atlas — Phase 1 Crystal + Phase 2 AlphaFold2 (CC BY-NC-ND 4.0)

Fiedler Inversion Score (FIS) v5: Human Proteome Atlas — Phase 1 (Crystal) + Phase 2 (AlphaFold2) This release supersedes FIS v4 (DOI: 10. 5281/zenodo. 20187798) and presents the complete two-phase analysis of the human proteome using the Fiedler Inversion Score geometric classification framework. Phase 1 (Crystal Structures — High Confidence): 2, 676 human proteins with PDB apo/holo crystal structure pairs. 100 Type II spring-loaded drug target candidates identified (3. 7%). Mann-Whitney U p = 1. 34e-24. LOO-CV: 98/100 stable. Fisher exact vs FDA-approved targets: OR = infinity, p 5 (spring-loaded). Type III: near-zero lambda2 (disordered). Files: fisₚipelineₙ100. py (reproducible pipeline), FISᵣesultsₙ100. csv (Phase 1), fisᵤnifiedₚroteome. csv (Phase 1+2 unified atlas, top 5, 000). --- COPYRIGHT AND LICENSING NOTICE Academic Use (CC BY-NC-ND 4. 0): This dataset, methodology, and all associated software are released under Creative Commons Attribution-NonCommercial-NoDerivatives 4. 0 International. You are free to share and cite for non-commercial academic purposes with attribution. Commercial Use — Separate License Required: Any commercial application of the Fiedler Inversion Score (FIS) framework, the Human Proteome FIS Atlas, or derivative works — including pharmaceutical drug target screening, computational drug discovery services, clinical diagnostics, bioinformatics platform integration, or licensing to third parties — requires a separate written commercial license from the copyright holder. Copyright (c) 2026 Kao, Yao-Kai. All commercial rights reserved. Institute of Brain Science, National Yang Ming Chiao Tung University (NYCU), Taiwan. Commercial licensing: jackykao@gm. nycu. edu. tw This dual-licensing structure ensures open academic access while preserving exclusive commercial rights to the FIS methodology and Human Proteome Atlas. The prior art established by this DOI series (first deposited: 2026-05-14, DOI: 10. 5281/zenodo. 20187798) constitutes the foundational IP record for all future commercial applications of the FIS framework. Part of the Geometric Systems Medicine series.