What is the clinical evidence from this study?

Study design: Other. Population: Ischemic stroke. Intervention: Interferometric Diffusion Speckle Contrast Analysis (iDSCA) vs. Transcranial Doppler (TCD). Primary outcome: Average relative blood flow index change rate in human in vivo experiments.

What question did this study set out to answer?

The research aims to validate the iDSCA system for detecting carotid blood flow changes as a warning for ischemic stroke.

May 19, 2026Journal of Biophotonics0 citations

View Full Paper

Research on Carotid Blood Flow Detection Based on Interferometric Diffuse Speckle Contrast Analysis and Its Application in Preventing Ischemic Stroke

GHGuang HanTianjin University of Technology WZWei ZhangTiangong University QYQinglong YangTiangong University

Key Result

The iDSCA system noninvasively detected an average relative blood flow index change of -23.38% in humans, consistent with Transcranial Doppler measurements (-20.43%).

Key Points

The research aims to validate the iDSCA system for detecting carotid blood flow changes as a warning for ischemic stroke.
Animal experiments combining color Doppler ultrasound and human in vivo experiments with Transcranial Doppler were conducted.
The iDSCA system was compared to traditional imaging techniques for changes in blood flow.
Average relative blood flow index changes were measured pre- and post-stenosis.
In animal experiments, iDSCA detected a blood flow index change of −56.66%, compared to −63.17% with color Doppler ultrasound.
In human experiments, the average blood flow index change detected was −23.38%, aligning with a −20.43% change from Transcranial Doppler.
The iDSCA system showed significant correlation in detecting hemodynamic changes in both animal and human experiments.

Structured PICO

Does the iDSCA system accurately detect changes in common carotid artery blood flow compared to standard Doppler ultrasound?

Population

Animal models and human subjects undergoing common carotid artery blood flow detection

Intervention

Interferometric Diffusion Speckle Contrast Analysis (iDSCA) system

Comparator

Color Doppler ultrasound (in animals) and Transcranial Doppler (in humans)

Outcome

Relative blood flow index change rate after stenosissurrogate

The novel iDSCA system can noninvasively and sensitively capture hemodynamic changes caused by common carotid artery stenosis, showing strong correlation with established Doppler ultrasound techniques.

Main Result

Absolute Event Rate: -23.38% vs -20.43%

Abstract

ABSTRACT This study applied the Interferometric Diffusion Speckle Contrast Analysis (iDSCA) system developed by our research group to detect changes in common carotid artery blood flow. Through animal experiments combining color Doppler ultrasound and human in vivo experiments integrating Transcranial Doppler, the iDSCA system was validated as a technical modality for early warning of ischemic stroke. The experimental results show that in animal experiments, the average relative blood flow index change rate detected by iDSCA after stenosis is −56.66%, which is consistent with the detection result of color Doppler ultrasound (−63.17%). In human in vivo experiments, the average rBFI (%) detected by iDSCA was −23.38%, consistent with the average rate of change in blood flow velocity (rMV(%) = −20.43%) measured by TCD. The iDSCA system has demonstrated significant correlation in both animal and in vivo experiments, confirming its ability to noninvasively and sensitively capture hemodynamic changes caused by CCA stenosis.

Ask AI

Helpful

Bookmark

View Full Paper

Ask AI

Helpful

Bookmark

View Full Paper

Research on Carotid Blood Flow Detection Based on Interferometric Diffuse Speckle Contrast Analysis and Its Application in Preventing Ischemic Stroke

Key Result

Key Points

Structured PICO

Main Result

Abstract

Cite This Study

Also Consider

Also Consider