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May 20, 2026Journal of the American College of Cardiology214 citationsOpen Access

Structure and Function of the Left Atrium and Left Atrial Appendage

VDVictoria DelgadoLBLuigi Di BiaseMLMelissa Leung

Key Result

Multimodality imaging provides a comprehensive evaluation of left atrial remodeling and offers parameters to identify patients at risk of atrial fibrillation and stroke.

Key Points

  • This review focuses on how to integrate multimodality imaging into the clinical management of patients at risk of atrial fibrillation and stroke.
  • Comprehensive evaluation of left atrial remodeling using multimodality imaging techniques.
  • Identification of parameters that help assess the risk of atrial fibrillation and stroke.
  • Left atrial remodeling contributes to the development of atrial fibrillation and stroke.
  • Multimodality imaging parameters can effectively identify patients at risk for these cardiovascular events.

Structured PICO

P
Population
Patients at risk of atrial fibrillation and stroke
E
Exposure
Multimodality imaging

Multimodality imaging provides a comprehensive evaluation of left atrial remodeling to identify patients at risk of atrial fibrillation and stroke.

Abstract

Atrial fibrillation (AF) and stroke are important major health problems that share common risk factors and frequently coexist. Left atrial (LA) remodeling is an important underlying substrate for AF and stroke. LA dilation and dysfunction form a prothrombotic milieu characterized by blood stasis and endothelial dysfunction. In addition, alterations of the atrial cardiomyocytes, increase of noncollagen deposits in the interstitial space and fibrosis, favor the occurrence of re-entry that predisposes to AF. Eventually, AF further impairs LA function and promotes LA remodeling, closing a self-perpetuating vicious circle. Multimodality imaging provides a comprehensive evaluation of several aspects of LA remodeling and offers several parameters to identify patients at risk of AF and stroke. How multimodality imaging can be integrated in clinical management of patients at risk of AF and stroke is the focus of the present review paper.

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Cite This Study

Delgado et al. (2017) conducted a review in Atrial fibrillation and stroke. Multimodality imaging was evaluated. Multimodality imaging provides a comprehensive evaluation of left atrial remodeling and offers parameters to identify patients at risk of atrial fibrillation and stroke.

synapsesocial.com/papers/6a0d2825ac869a42b5f8557fhttps://doi.org/10.1016/j.jacc.2017.10.063
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left Atrial Appendage2010 · 644 citations
  2. 2Loss of Continuity in the Thin Epicardial Layer Because of Endomysial Fibrosis Increases the Complexity of Atrial Fibrillatory Conduction2013 · 134 citations
  3. 3Predictors of Thromboembolism in Atrial Fibrillation: II. Echocardiographic Features of Patients at Risk1992 · 544 citations
  4. 4Quantitative Tissue‐Tracking Cardiac Magnetic Resonance (CMR) of Left Atrial Deformation and the Risk of Stroke in Patients With Atrial Fibrillation2015 · 72 citations
  5. 5Left atrial appendage occlusion: rationale, evidence, devices, and patient selection2016 · 74 citations