Protein binding regulates complex configuration: comparative analysis of three dynamically racemic europium( iii ) complexes | Synapse
May 20, 2026Open Access
Protein binding regulates complex configuration: comparative analysis of three dynamically racemic europium( iii ) complexes
Key Points
This research investigates how protein binding affects the structural configuration of europium(III) complexes, focusing on their enantiomeric forms.
Comparative analysis of europium(III) complexes with human serum albumin and bovine serum albumin.
Measurement of chiroptical properties to determine binding characteristics and enantiomer predominance.
Eu(III) complex predominantly binds as the Λ enantiomer to human serum albumin.
Binding to bovine serum albumin favors the Δ isomer, illustrating different binding preferences.
Abstract
Induced Eu CPL signatures of opposite sign show that the same Eu( iii ) complex binds predominantly as the Λ enantiomer to human serum albumin, and as the Δ isomer to bovine serum albumin.