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May 20, 2026American Journal of Respiratory and Critical Care Medicine

B48-40 From Stroke to Silence: A Case of a Partial Locked-in Syndrome Due to Isolated Ventral Pontine Ischemic Stroke

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Authors

GCG CarusoOJO JahangiriANA Navarro

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Overview

Case report demonstrates locked-in syndrome from bilateral pontine ischemic stroke, indicating treatment challenges.

Key Points

  • The aim is to highlight a rare case of partial locked-in syndrome following bilateral pontine ischemic stroke.
  • Case report of a 54-year-old male with bilateral pontine ischemic stroke.
  • Patient treated with tenecteplase for presumed ischemic stroke and monitored for progressive symptoms.
  • MRI conducted to assess pontine diffusion restriction.
  • Patient exhibited quadriplegia and aphasia following stroke, necessitating tracheostomy.
  • MRI revealed central pontine diffusion restriction without signs of hemorrhage.
  • Locked-in syndrome resulting from pontine ischemia carries a high mortality rate (70-80%).

Cite This Study

Caruso et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4f19f03e14405aa9a5d7https://doi.org/10.1093/ajrccm/aamag162.1366
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The anatomy of concealed awareness: lessons from partial locked-in syndrome2026
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  4. 4Lacunar Pontine Infarct Presenting as Ipsilateral Lower Motor Neuron Facial Palsy: A Case Report2026
  5. 5Acute peripheral facial paralysis caused by tegmental pontine infarction2024 · 4 citations