What question did this study set out to answer?

This study aims to assess CT-derived perfusion imaging (CTP) as a contrast-free alternative for diagnosing pulmonary embolism (PE).

May 20, 2026American Journal of Respiratory and Critical Care Medicine0 citations

Characterizing Pulmonary Embolism Using Non-Contrast CT Imaging in an Animal Model

A67-16 Characterizing Pulmonary Embolism From Non-Contrast Computed Tomography Imaging in an Animal Model

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Authors

BEB M Evans HKH Kuo JJJ R Joseph

Discussion

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Overview

Pre-clinical study demonstrates CTP imaging effectively diagnoses pulmonary embolism in an animal model, suggesting a vital alternative to conventional methods.

Key Points

This study aims to assess CT-derived perfusion imaging (CTP) as a contrast-free alternative for diagnosing pulmonary embolism (PE).
Conducted a pre-clinical study using three female C57BL/6 mice implanted with synthetic emboli.
Utilized CTP algorithms to analyze changes in thoracic 4DCT images for quantifying perfusion.
Employed image registration to track mass changes between inhale and exhale phases.
Mouse A displayed a 7% CTP drop in the PE lung, with a 12% increase in the healthy lung.
Mouse B exhibited an 8% CTP drop in the PE lung and a similar 12% increase in the healthy lung.
Increased CTP in healthy lungs indicates a potential compensatory mechanism following embolism.

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Cite This Study

Evans et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4f34f03e14405aa9a60b https://doi.org/10.1093/ajrccm/aamag162.1345

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May 20, 2026American Journal of Respiratory and Critical Care Medicine0 citations

Characterizing Pulmonary Embolism Using Non-Contrast CT Imaging in an Animal Model

A67-16 Characterizing Pulmonary Embolism From Non-Contrast Computed Tomography Imaging in an Animal Model

View Full Paper

Authors

BEB M Evans HKH Kuo JJJ R Joseph

Discussion

Member takes

Overview

Pre-clinical study demonstrates CTP imaging effectively diagnoses pulmonary embolism in an animal model, suggesting a vital alternative to conventional methods.

Key Points

This study aims to assess CT-derived perfusion imaging (CTP) as a contrast-free alternative for diagnosing pulmonary embolism (PE).
Conducted a pre-clinical study using three female C57BL/6 mice implanted with synthetic emboli.
Utilized CTP algorithms to analyze changes in thoracic 4DCT images for quantifying perfusion.
Employed image registration to track mass changes between inhale and exhale phases.
Mouse A displayed a 7% CTP drop in the PE lung, with a 12% increase in the healthy lung.
Mouse B exhibited an 8% CTP drop in the PE lung and a similar 12% increase in the healthy lung.
Increased CTP in healthy lungs indicates a potential compensatory mechanism following embolism.

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View Full Paper

Cite This Study

Evans et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4f34f03e14405aa9a60b https://doi.org/10.1093/ajrccm/aamag162.1345

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