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May 20, 2026American Journal of Respiratory and Critical Care Medicine

D95-02 Detailing the Extracellular Matrix Shifts in Bronchopulmonary Dysplasia Using Spatial Multi-omics

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Authors

GCG C ClairBGB GormanNBN Beishembieva

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Overview

Randomized trial investigates ECM remodeling in bronchopulmonary dysplasia, suggesting new therapeutic strategies.

Key Points

  • This research aims to investigate molecular changes in the extracellular matrix associated with bronchopulmonary dysplasia.
  • Developed a spatial multi-omics workflow using tissue samples from donors with bronchopulmonary dysplasia.
  • Combined mass spectrometry imaging for N-glycans and ECM proteins with multiplexed immunofluorescence.
  • Analyzed data with RomicsProcessor to explore ECM composition in various lung compartments.
  • Identified over 16,000 peptides from 125 ECM proteins; significant changes in specific lung regions associated with BPD.
  • Notable increases in COL1 and COL14 in smooth muscle areas; remodeling in alveolar parenchyma with varying collagen levels.
  • Spatial glycobiology showed increased glycans indicating altered cell signaling in diseased lung tissue.

Cite This Study

Clair et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4fd2f03e14405aa9b48fhttps://doi.org/10.1093/ajrccm/aamag162.1214
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