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This report examines the electrographic effects of intrathecal baclofen overdose following treatment for spasticity.

May 20, 2026Open Access

An unusual case of burst suppression electrographic pattern following intrathecal baclofen overdose in critical care: a case report

Puntos clave

This report examines the electrographic effects of intrathecal baclofen overdose following treatment for spasticity.
Described a single case of baclofen overdose in an intensive care unit.
Performed an electroencephalogram (EEG) to assess neurological impact post-anoxic encephalopathy.
Identified burst suppression pattern on EEG in the context of baclofen overdose.
Highlighted the need for further characterization of neurological consequences associated with intrathecal baclofen.

Resumen

Baclofen is a gamma-aminobutyric acid (GABA)-B receptor agonist used to treat neurological spasticity. Several cases of baclofen intoxication have been reported with neurological symptoms. While numerous reports describe oral baclofen toxicity, the neurological consequence of intrathecal overdose remain poorly characterised. We describe an electroencephalogram (EEG) post-anoxic encephalopathy pattern following intrathecal BACLOFEN injection to treat spasticity in an intensive care unit in September 2024.

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