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May 20, 2026Ophthalmic and Physiological OpticsOpen Access

Dose-Dependent Effects of Atropine on Accommodative and Binocular Visual Function for Myopia Control in Children: A Systematic Review and Meta-Analysis

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Authors

CMClara Martinez-PerezJSJacinto Santodomingo-RubidoCVCésar Villa-Collar

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Overview

Randomized trial evaluates atropine's effects on visual function in children, suggesting dose-dependency.

Key Points

  • This research aims to determine how different concentrations of atropine affect visual functions in children with myopia.
  • Conducted a systematic review and meta-analysis of randomized controlled trials registered in PROSPERO.
  • Studies compared atropine eye drops (0.01-1%) with placebos or no treatment and assessed visual outcomes.
  • Utilized fixed- or random-effects models to analyze mean differences in outcomes.
  • Low-dose atropine (0.01%) showed a small significant reduction in accommodative amplitude (MD: -0.84 D, 95% CI: -1.50 to -0.18).
  • Atropine 0.05% led to a clinically meaningful reduction in accommodative amplitude (MD: -1.96 D, 95% CI: -2.36 to -1.57).
  • Higher concentrations (≥0.1%) caused noticeable cycloplegic effects on visual function.

Cite This Study

Martinez-Perez et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5013f03e14405aa9b98chttps://doi.org/10.1007/s44402-026-00093-5
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