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May 20, 2026American Journal of Respiratory and Critical Care Medicine

D102-18 Comparative Effectiveness of Cytisinicline and Varenicline for Smoking Cessation: A Matching-adjusted Indirect Comparison (MAIC)

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Authors

MRM RubinsteinDRD RoweRPR Perdok

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Overview

Randomized trial compares efficacy of cytisinicline and varenicline for smoking cessation, highlighting improved tolerance.

Key Points

  • The research aims to compare the efficacy and safety of cytisinicline and varenicline for smoking cessation.
  • Conducted a matching-adjusted indirect comparison using data from Phase 3 trials.
  • Compared continuous abstinence rates over 12 and 24 weeks for cytisinicline and varenicline.
  • Weighted individual patient data to match baseline characteristics of varenicline cohorts.
  • At 9-12 weeks, the continuous abstinence rates were comparable (adjusted ORs 1.32-1.33).
  • At 9-24 weeks, cytisinicline showed higher abstinence rates compared to varenicline (adjusted ORs 1.90-2.13).
  • Cytisinicline had a significantly lower incidence of nausea (adjusted ORs 0.18-0.13) compared to varenicline.

Cite This Study

Rubinstein et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5013f03e14405aa9bab5https://doi.org/10.1093/ajrccm/aamag162.6534
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