What does this research mean for the field?

Metagenomic sequencing of cerebrospinal fluid can successfully diagnose West Nile Virus neuroinvasive disease in immunocompromised patients when standard serological testing is falsely negative. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To report a case of Guillain-Barré Syndrome due to West Nile Virus in an immunocompromised patient treated with rituximab.

May 20, 2026American Journal of Respiratory and Critical Care Medicine

C50-32 West Nile Virus Presenting as Guillain-Barré Syndrome in an Immunocompromised Patient: A Diagnostic Challenge

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Authors

SAS Asif SSS Shah MHM Hafiz

Discussion

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Overview

Case presentation shows detection of West Nile Virus RNA via metagenomic sequencing in an immunocompromised patient, indicating diagnostic challenges.

Key Points

To report a case of Guillain-Barré Syndrome due to West Nile Virus in an immunocompromised patient treated with rituximab.
Detailed clinical evaluation of a 63-year-old woman with progressive weakness and respiratory failure.
Cerebrospinal fluid analysis and metagenomic sequencing were performed to identify pathogen.
Imaging studies including MRI of the brain and spine were conducted to assess CNS involvement.
Metagenomic sequencing detected West Nile Virus RNA in cerebrospinal fluid on day 12 after inconclusive serologies.
Cerebrospinal fluid showed albumin-cytologic dissociation but was negative for pathogens.
Patient required intubation due to respiratory distress and experienced no clinical improvement despite five plasmapheresis sessions.

Cite This Study

Asif et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5051f03e14405aa9bf5c https://doi.org/10.1093/ajrccm/aamag162.3277

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May 20, 2026American Journal of Respiratory and Critical Care Medicine

C50-32 West Nile Virus Presenting as Guillain-Barré Syndrome in an Immunocompromised Patient: A Diagnostic Challenge

View Full Paper

Ask AI

Bookmark

Authors

SAS Asif SSS Shah MHM Hafiz

Discussion

Member takes

Overview

Case presentation shows detection of West Nile Virus RNA via metagenomic sequencing in an immunocompromised patient, indicating diagnostic challenges.

Key Points

To report a case of Guillain-Barré Syndrome due to West Nile Virus in an immunocompromised patient treated with rituximab.
Detailed clinical evaluation of a 63-year-old woman with progressive weakness and respiratory failure.
Cerebrospinal fluid analysis and metagenomic sequencing were performed to identify pathogen.
Imaging studies including MRI of the brain and spine were conducted to assess CNS involvement.
Metagenomic sequencing detected West Nile Virus RNA in cerebrospinal fluid on day 12 after inconclusive serologies.
Cerebrospinal fluid showed albumin-cytologic dissociation but was negative for pathogens.
Patient required intubation due to respiratory distress and experienced no clinical improvement despite five plasmapheresis sessions.

Cite This Study

Asif et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5051f03e14405aa9bf5c https://doi.org/10.1093/ajrccm/aamag162.3277

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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