B43-52 Pulmonary Manifestation of Sjogren’s Syndrome

Abstract Pulmonary nodular lymphoid hyperplasia (PNLH) is a rare benign lymphoproliferative disorder and an uncommon pulmonary manifestation of Sjögren’s syndrome. We report the case of a 78-year-old woman with biopsy-proven seronegative primary Sjögren’s syndrome on Rituximab who presented with recurrent pneumonia, chronic dry cough, and fatigue. High-resolution CT of the chest demonstrated multiple airspace opacities, a right upper lobe nodule, cysts, and bronchiectasis. CT-guided biopsy of the nodule revealed dense polyclonal lymphoid infiltrates with reactive germinal centers and fibrosis, consistent with PNLH. Congo red and IgG4 stains were negative, and no features of lymphoma were identified. This case highlights the importance of considering benign lymphoproliferative conditions such as PNLH in Sjögren’s syndrome when pulmonary nodules or consolidations are detected, to avoid misdiagnosis as malignant lymphoma and to guide appropriate management. This abstract is funded by: None