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May 20, 2026American Journal of Respiratory and Critical Care Medicine

A95-05 Deep Learning-derived Fibrotic and Inflammatory Phenotypes Predict Lung Function Across Idiopathic and Connective-tissue-related Interstitial Lung Disease

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Authors

SWS L WalshRKR KeeganNDN Dinsdale

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Overview

Randomized trial examines lung function outcomes in interstitial lung disease, highlighting imaging phenotypes' predictive power.

Key Points

  • The study aims to investigate how deep-learning derived imaging phenotypes relate to lung function in patients with interstitial lung disease.
  • Analysis of HRCT scans from 384 patients with idiopathic pulmonary fibrosis and connective-tissue-related interstitial lung disease using quantitative CT models.
  • Patients categorized into fibrotic-predominant, inflammatory-predominant, or mixed phenotypes based on fibrosis and ground glass opacities.
  • Assessment of lung function via forced vital capacity paired with HRCT scans.
  • Fibrotic-predominant pattern found in 78% (n=299), with mean ppFVC of 76.9±18.8%.
  • Inflammatory-predominant cases had ppFVC of 82.1±19.3%, +5.1% increase compared to fibrotic cases (p=0.074).
  • Each unit increase in fibrosis-to-inflammation ratio correlated with a 0.35% decrease in ppFVC (β=-0.35 ± 0.07, p<0.001).

Cite This Study

Walsh et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5051f03e14405aa9bfd7https://doi.org/10.1093/ajrccm/aamag162.2391
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1B23-07 Quantitative Computed Tomography Analysis Distinguishes Acute Exacerbation From Progressive Fibrosing Phenotypes in Interstitial Lung Disease2026
  2. 2B23-15 Structure-function Coupling and Quantitative Imaging Biomarkers in Polymyositis Dermatomyositis Associated Interstitial Lung Disease2026
  3. 3B23-11 Extent of Lung Fibrosis by Deep Learning-Based Quantitative CT Is the Strongest Predictor of Mortality in Idiopathic Pulmonary Fibrosis: A Retrospective, Multicenter Study2026
  4. 4C39-40 Imaging-Physiology Dissociation and the Role of Pulmonary Vasculature in Systemic Sclerosis-Associated ILD2026
  5. 5B23-20 Quantitative CT Detects Changes in Parenchymal, Airway and Vascular Features in Familial Pulmonary Fibrosis Relatives With Interstitial Lung Abnormalities2026