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This research investigates how IRE1 signaling affects sialic acid production in lung epithelial cells and influences influenza infection in asthma.

D18-07 IRE1 Signaling as a Regulator of Sialic Acid Production: Impacts on Influenza Infection in Asthma

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Randomized trial examines IRE1's role in sialic acid production and influenza response in asthma, suggesting therapeutic targets.

This research investigates how IRE1 signaling affects sialic acid production in lung epithelial cells and influences influenza infection in asthma.
RNA-seq analysis of bronchial brushings from asthmatic patients for IRE1 signaling and SA regulation
In vitro experiments with HBEC3KT cells treated with IRE1 inhibitors and infected with H3N2 IAV
In vivo studies involving IRE1α and ATF6 knockout mice sensitized to HDM and infected with H3N2.
IRE1 signaling was elevated in asthmatic lungs, correlating with increased sialic acid transferase activity.
IRE1 inhibition in vitro led to a reduction in sialic acids and influenza viral titers.
In vivo IRE1α knockout resulted in lower sialic acids, reduced immune cell recruitment, and improved oxygen saturation during influenza infection.

Walzer et al. (2026) studied this question.

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View Full Paper

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Authors

Randomized trial examines IRE1's role in sialic acid production and influenza response in asthma, suggesting therapeutic targets.

This research investigates how IRE1 signaling affects sialic acid production in lung epithelial cells and influences influenza infection in asthma.
RNA-seq analysis of bronchial brushings from asthmatic patients for IRE1 signaling and SA regulation
In vitro experiments with HBEC3KT cells treated with IRE1 inhibitors and infected with H3N2 IAV
In vivo studies involving IRE1α and ATF6 knockout mice sensitized to HDM and infected with H3N2.
IRE1 signaling was elevated in asthmatic lungs, correlating with increased sialic acid transferase activity.
IRE1 inhibition in vitro led to a reduction in sialic acids and influenza viral titers.
In vivo IRE1α knockout resulted in lower sialic acids, reduced immune cell recruitment, and improved oxygen saturation during influenza infection.

Walzer et al. (2026) studied this question.

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