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May 20, 2026American Journal of Respiratory and Critical Care Medicine

D16-01 Spatial Transcriptomic Atlas of the Human Lung in Pulmonary Arterial Hypertension

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Authors

ABA J BrownsteinBWB WongAGA Gandjeva

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Overview

Randomized trial reveals gene dysregulation in pulmonary arterial hypertension, suggesting new therapeutic targets.

Key Points

  • To uncover insights into the disease mechanisms of pulmonary arterial hypertension through spatial transcriptomic profiling.
  • Spatial transcriptomic analysis of lung tissue samples from 73 individuals, 47 with PAH.
  • Quality control measures applied to remove low-quality transcripts and cells.
  • Differential gene expression analyzed using edgeR and gene set enrichment analysis with Hallmark pathways.
  • 39 unique cell types identified in lung samples.
  • Significant differential expression of genes (FDR < 0.05) between PAH and control lungs.
  • Increased myofibroblast abundance in PAH correlated with higher pulmonary vascular resistance.

Cite This Study

Brownstein et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5064f03e14405aa9c1a2https://doi.org/10.1093/ajrccm/aamag162.5873
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1D16-05 Single-Cell Resolution Spatial Transcriptomics Reveals Dysregulation of Fibroblasts and Arterial Endothelial Cells in Human Pulmonary Arterial Hypertension2026
  2. 2C26-04 Profiling Spatial Interactions Related With Endothelial Cells in Severe Pulmonary Hypertension Using High-resolution Spatial Transcriptomics2026
  3. 3D106-09 Transcriptomic Signatures of Pulmonary Arterial Lesions in Connective Tissue Disease Associated Pulmonary Arterial Hypertension2026
  4. 4Transcriptional profiles of pulmonary artery endothelial cells in pulmonary hypertension2023 · 32 citations
  5. 5Identification of hub genes based on integrated analysis of single-cell and microarray transcriptome in patients with pulmonary arterial hypertension2023 · 19 citations