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May 20, 2026Journal of Gastroenterology and Hepatology

Circulating Tumor DNA and Precision Biomarkers in Colorectal Cancer: Implications for Diagnosis, Monitoring, and Management of Advanced Disease

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Authors

VSVijay Kumar SrinivasaluNSNarayana SubramaniamMIMohammed Ibrahim

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Overview

Narrative review synthesizes findings on biomarkers improving colorectal cancer diagnosis and treatment, indicating future potential.

Key Points

  • This review aims to synthesize evidence on evolving biomarkers in colorectal cancer for diagnosis and management.
  • Narrative review of 73 human studies published from 2010 to 2024.
  • Structured searches conducted in PubMed, Embase, Web of Science, and Cochrane Library.
  • Quality assessment performed using QUADAS‐2 and Newcastle‐Ottawa tools.
  • Circulating tumor DNA (ctDNA) showed superior performance in minimal residual disease detection and therapy monitoring.
  • Stool DNA methylation assays exhibited strong sensitivity for early colorectal cancer detection.
  • Genomic markers directly informed targeted therapy selection and immune biomarkers guided immunotherapy decisions.

Cite This Study

Srinivasalu et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5078f03e14405aa9c355https://doi.org/10.1111/jgh.70420
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  3. 3Integrated Molecular, Epigenetic, Microbial, and Liquid Biopsy Biomarkers in Colorectal Cancer: Implications for Prognosis and Precision Therapy2026
  4. 4Screening, Prognostic, and Predictive Molecular Tools for Colorectal Cancer: Recent Advances in the Classical Background2026 · 7 citations
  5. 5Stage-specific circulating transcriptomic and proteomic biomarkers and regulators in colorectal cancer: bridging affordable diagnostics and translational therapeutics2026