What question did this study set out to answer?

To highlight the diagnostic challenges and treatment effectiveness for granulomatosis with polyangiitis (GPA), particularly when presenting with isolated lung lesions.

May 20, 2026American Journal of Respiratory and Critical Care Medicine

B35-31 Evolving Granulomatous Lung Lesion Revealing Granulomatosis With Polyangiitis

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Authors

ACA J Jaramillo Canas NVN Varghese MTM Tahboub

Discussion

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Overview

Case describes diagnosis and treatment of granulomatosis with polyangiitis in a woman with complex lung lesions, indicating the need for vigilant monitoring.

Key Points

To highlight the diagnostic challenges and treatment effectiveness for granulomatosis with polyangiitis (GPA), particularly when presenting with isolated lung lesions.
Case report of a 59-year-old woman with respiratory symptoms and imaging findings suggestive of GPA.
Biopsies and laboratory tests were conducted to identify granulomatous inflammation and confirm GPA diagnosis.
Treatment involved corticosteroids, methotrexate, and intravenous cyclophosphamide for management of systemic involvement.
Initial biopsies showed focal necrosis without malignancy, and corticosteroids led to partial regression of lung lesions.
Subsequent renal biopsy confirmed crescentic pauci-immune glomerulonephritis, indicative of systemic GPA.
Induction therapy with cyclophosphamide stabilized renal function and resulted in further lung lesion improvement.

Cite This Study

Canas et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5089f03e14405aa9c550 https://doi.org/10.1093/ajrccm/aamag162.758

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May 20, 2026American Journal of Respiratory and Critical Care Medicine

B35-31 Evolving Granulomatous Lung Lesion Revealing Granulomatosis With Polyangiitis

View Full Paper

Ask AI

Bookmark

Authors

ACA J Jaramillo Canas NVN Varghese MTM Tahboub

Discussion

Member takes

Overview

Case describes diagnosis and treatment of granulomatosis with polyangiitis in a woman with complex lung lesions, indicating the need for vigilant monitoring.

Key Points

To highlight the diagnostic challenges and treatment effectiveness for granulomatosis with polyangiitis (GPA), particularly when presenting with isolated lung lesions.
Case report of a 59-year-old woman with respiratory symptoms and imaging findings suggestive of GPA.
Biopsies and laboratory tests were conducted to identify granulomatous inflammation and confirm GPA diagnosis.
Treatment involved corticosteroids, methotrexate, and intravenous cyclophosphamide for management of systemic involvement.
Initial biopsies showed focal necrosis without malignancy, and corticosteroids led to partial regression of lung lesions.
Subsequent renal biopsy confirmed crescentic pauci-immune glomerulonephritis, indicative of systemic GPA.
Induction therapy with cyclophosphamide stabilized renal function and resulted in further lung lesion improvement.

Cite This Study

Canas et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5089f03e14405aa9c550 https://doi.org/10.1093/ajrccm/aamag162.758

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