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May 20, 2026American Journal of Respiratory and Critical Care Medicine

C105-25 High-flow Nasal Cannula vs. Non-invasive Ventilation in Adults With Acute Hypoxemic Respiratory Failure: A Systematic Review and Meta-analysis

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Authors

ABA BajwaKZK ZahoorSAS Ansari

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Overview

Systematic review compares the effects of high-flow nasal cannula and non-invasive ventilation on mortality in adults with acute hypoxemic respiratory failure, suggesting similar outcomes.

Key Points

  • The central aim is to compare the efficacy of high-flow nasal cannula (HFNC) and non-invasive ventilation (NIV) in improving outcomes for adults with acute hypoxemic respiratory failure.
  • Conducted a systematic review and meta-analysis of randomized controlled trials and cohort studies published from 2010 to 2025.
  • Searches were conducted in major databases including PubMed and Cochrane Library using specific keywords.
  • Data synthesis and analysis were performed using RevMan software to calculate pooled odds ratios and relative risks.
  • 28-day mortality showed no significant difference between HFNC and NIV (RR 0.97, 95% CI 0.80-1.16; p=0.71).
  • The need for endotracheal intubation was not significantly different (OR 0.76, 95% CI 0.55-1.06; p=0.11).
  • Secondary outcomes, including complications and oxygenation improvement measures, were comparable between both interventions.

Cite This Study

Bajwa et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5089f03e14405aa9c5d5https://doi.org/10.1093/ajrccm/aamag162.3333
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