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May 20, 2026American Journal of Respiratory and Critical Care Medicine0 citations

Lung Barrier Dysfunction in Bronchopulmonary Dysplasia Identified by Spatial Transcriptomics

B28-15 Compromised Lung Barrier Dysfunction in Bronchopulmonary Dysplasia Identified Through Spatial Transcriptomics

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Authors

TKT M KingACA A ColborgJRJ J Rojas-Quintero

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Overview

Randomized trial observes compromised lung barrier function in infants with bronchopulmonary dysplasia, suggesting new therapeutic targets.

Key Points

  • This research aims to characterize the cellular and transcriptomic landscape of the lungs in bronchopulmonary dysplasia (BPD) to identify dysfunctions.
  • Analyzed FFPE lung sections from 9 premature infants with BPD, 6 control premature infants, and 9 full-term infants.
  • Implemented genome-wide spatial transcriptomics and gene ontology enrichment analysis.
  • Conducted immunofluorescence on identified molecular targets for confirmation.
  • Significant downregulation of CC16 and cilia-associated proteins in BPD airways confirmed by immunofluorescence.
  • BPD lung parenchyma exhibited reduced surfactant proteins A and D with elevated antimicrobial peptides due to inflammation.
  • Altered cellular composition noted with fewer club and mucociliary cells, indicating potential for increased infection susceptibility.
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Cite This Study

King et al. (2026) studied this question.

synapsesocial.com/papers/6a0d50bdf03e14405aa9cca5https://doi.org/10.1093/ajrccm/aamag162.1142
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