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May 20, 2026American Journal of Therapeutics

Tradipitant: A Novel Neurokinin-1 Receptor Antagonist for Motion Sickness

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Authors

TNTimothy NguyenKWKristine C. WillettLDLaura R. Daly

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Overview

Randomized trial shows tradipitant prevents motion sickness symptoms in adults, suggesting a novel treatment option.

Key Points

  • To evaluate the efficacy and tolerate of tradipitant, a neurokinin-1 receptor antagonist, for motion sickness prevention.
  • Two phase 3 pivotal trials: Motion Syros (N=365) and Motion Serifos (N=316)
  • Participants were randomly assigned to receive either tradipitant or placebo in a double-blinded manner
  • Primary outcome measured was incidence of vomiting associated with motion sickness.
  • In Motion Syros, tradipitant 170 mg had an incidence of vomiting at 18.3% vs placebo at 44.3% (P=0.00002)
  • In Motion Serifos, the incidence for 170 mg tradipitant was 10.4% compared to 37.7% for placebo (P=0.0014)
  • Tradipitant was well-tolerated with no serious adverse events reported.

Cite This Study

Nguyen et al. (2026) studied this question.

synapsesocial.com/papers/6a0d50f3f03e14405aa9d242https://doi.org/10.1097/mjt.0000000000002147
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tradipitant (Nereus) for Motion Sickness2026
  2. 2Tradipitant Effective in the Reduction of Vomiting Associated with Motion Sickness Across Varied Sea Conditions (S3.003)2024
  3. 3Management of Trastuzumab Deruxtecan-related nausea and vomiting in real-world practice2024 · 13 citations
  4. 4Dual-Targeted Antiemetic Strategy: A Review of Granisetron-Scopolamine Transdermal Patch for PONV and CINV Management2026
  5. 5Moving beyond promethazine: Advancing precision in antiemetic therapy2026