Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 20, 2026American Journal of Respiratory and Critical Care Medicine

A106-17 Association Between Genetic Ancestry and Urinary Metabolites of Extremely Premature Infants at High Risk of Developing Bronchopulmonary Dysplasia

View Full Paper
Ask AI
Bookmark
Share

Authors

TMT I Malave-MendezMGM A GuardadoCCC Chapin

Discussion

Loading...

Member takes

Overview

Randomized trial identifies urinary metabolites linked to genetic ancestry in premature infants, suggesting ancestry affects disease risk.

Key Points

  • Identify urinary metabolites associated with genetic ancestry in premature infants at high risk for bronchopulmonary dysplasia.
  • Performed untargeted metabolomics on 342 urine samples from 171 premature infants from the TOLSURF cohort.
  • Analyzed metabolites at two timepoints between days 5-15 and 23-32 postnatal age using linear regression, adjusting for various factors.
  • Stratified analyses by maternal race/ethnicity to evaluate associations with genomic ancestry.
  • 980 metabolites across 92 metabolic sub-pathways identified; 92 metabolites associated with African ancestry at timepoint 1 (p < 0.05).
  • At timepoint 2, 30 metabolites associated with African, 19 with Amerindigenous, and 12 with European ancestry (p < 0.05).
  • 13 metabolites consistently associated with the same ancestry at both timepoints, linked to pathways relevant in bronchopulmonary dysplasia.

Cite This Study

Malave-Mendez et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5114f03e14405aa9d587https://doi.org/10.1093/ajrccm/aamag162.1134
View Full Paper
Ask AI
Bookmark
Share