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May 20, 2026NutrientsOpen Access

Glutamine Starvation Induces Ferroptosis in NSCLC via AMPK/PDZD8-Mediated Ferritinophagy

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Authors

HCHong ChenXWXiaoying WuMZMeng Zhu

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Overview

Randomized trial reveals glutamine starvation drives ferroptosis in NSCLC, suggesting new dietary therapies.

Key Points

  • This study aims to explore how glutamine starvation affects ferroptosis in non-small cell lung cancer (NSCLC).
  • Evaluated glutamine starvation effects in A549 and H460 NSCLC cell lines and SCID mice xenograft models.
  • Analyzed cell viability, migration, clonogenic capacity, and expression of ferritinophagy and ferroptosis markers.
  • Manipulated AMPK activity through overexpression and inhibition to uncover mechanistic insights.
  • Glutamine starvation significantly suppressed tumor growth and reduced cell migration and clonogenicity.
  • Activated AMPK led to increased PDZD8 expression and modulation of ferritinophagy and ferroptosis markers.
  • Overexpression of PDZD8 was sufficient to promote ferritinophagy and ferroptosis in NSCLC cells.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5122f03e14405aa9d79bhttps://doi.org/10.3390/nu18101596
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