Background: The abuse of antibiotics has led to antibiotic-resistant bacteria that threaten human health. Nickel, with strong antibacterial activity and low likelihood of inducing bacterial resistance, has become a preferred material for wound infection prevention. Methods: Surface-modified nickel nanoparticles were prepared via isopropanol modification. The dilution coating plate method was used to test their antibacterial activity against Gram-negative E. coli and Gram-positive MRSA. Fifteen mice were randomly divided into PBS, low-concentration and high-concentration nickel nanoparticle groups. An MRSA-infected wound model was established on mice. Wound healing was monitored, and tissue staining, organ observation, and blood biochemical tests were performed. Results: The antibacterial effect of nickel nanoparticles was concentration-dependent, inhibiting over 90% of both bacteria at 200 μg/mL. The high-concentration group achieved wound healing rates of 92.7 and 97.4% on days 5 and 7, with the highest collagen ratio (43.1%) and thinner epithelial thickness. No obvious organ lesions or significant blood biochemical differences were observed across groups. Conclusions: The surface-modified nickel nanoparticles have high biosafety, good antibacterial properties, and can effectively kill bacteria in the wound area, thus promoting the healing of bacterial infection.
Fan et al. (Mon,) studied this question.