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May 21, 2026Case Reports in Oncology0 citationsOpen Access

Accelerated Cataract Progression with Olaparib and Bevacizumab in Fallopian Tube Carcinoma

Accelerated Bilateral Cataract Progression during Olaparib plus Bevacizumab Maintenance Therapy for High-Grade Serous Fallopian Tube Carcinoma: A Case Report

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Authors

WSWataru SaitoKOKuniaki OtaHOHana Okamoto

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Overview

Case Report uncovers cataract formation in high-grade serous carcinoma patients during maintenance therapy, suggesting a new ocular toxicity.

Key Points

  • To report a case of accelerated bilateral cataract progression in a patient undergoing olaparib plus bevacizumab therapy.
  • Case report of a 66-year-old woman with high-grade serous carcinoma and BRCA mutation.
  • Neoadjuvant chemotherapy followed by debulking surgery and maintenance therapy with olaparib and bevacizumab.
  • Ophthalmologic evaluations post-treatment to assess cataract development.
  • Patient developed a hypermature cataract in the right eye after three cycles of therapy, requiring surgical intervention.
  • A contralateral mature cataract was identified, becoming symptomatic shortly after right-eye surgery.
  • Postoperative recovery was excellent, but the rapid cataract progression suggests a possible treatment-related effect.

Cite This Study

Saito et al. (2026) studied this question.

synapsesocial.com/papers/6a0ea188be05d6e3efb605c7https://doi.org/10.1159/000551721
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