Asymmetric Transfer Hydrogenation of gem-Diester-substituted Cyclopropenes Enables the Synthesis of γ-Amino-acid Derivatives and γ-Lactams Bearing Multiple Stereocenters

Key Points

• The aim is to develop a general method for synthesizing both γ-amino-acid derivatives and γ-lactams using asymmetric transfer hydrogenation.
• Used asymmetric transfer hydrogenation on gem-diester-substituted cyclopropenes and γ-lactams.
• Focus on achieving multiple stereocenters in the synthesized products.
• Successful synthesis of γ-amino-acid derivatives with high stereoselectivity indicated by specific yield percentages.
• Creation of γ-lactams with multiple stereocenters, providing a pathway for complex molecular skeletons.