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Gastrointestinal cancers remain major health burdens due to poor survival and limited treatment options. Traditional Thai herbal remedies contain bioactive compounds with antioxidant and anticancer potential. This study evaluated the phytochemical profile, antioxidant capacity, and in vitro anticancer potential of Pikat Trichintalamaka (PTL), a traditional polyherbal formulation. PTL exhibited high flavonoid (474.17 ± 0.32 mg QE/g dry wt) and phenolic contents (399.54 ± 0.06 mg GAE/g dry wt), along with strong antioxidant activity via DPPH and FRAP assays. ¹H-NMR analysis identified key metabolites, including amino acids, vitamins, short-chain fatty acids, and polyphenols. PTL demonstrated significant time-dependent antiproliferative effects against KKU-100 cholangiocarcinoma and AGS gastric cancer cell lines. The anticancer activity likely stems from combination interactions among its phytochemical constituents and antioxidant properties. These findings position PTL as a promising natural candidate for gastrointestinal cancer treatment, though further in vivo and clinical studies are required to confirm safety and therapeutic efficacy.
Techasen et al. (Tue,) studied this question.