An elevated lactate dehydrogenase-to-albumin ratio was independently associated with a significantly increased risk of left ventricular aneurysm development in STEMI patients undergoing primary PCI (OR 3.63).
Cohort (n=2,406)
Yes
Does an elevated lactate dehydrogenase-to-albumin ratio predict the development of left ventricular aneurysm in STEMI patients undergoing primary PCI?
An elevated lactate dehydrogenase-to-albumin ratio (LAR) measured at admission is a strong, independent predictor of left ventricular aneurysm formation in STEMI patients undergoing primary PCI.
Effect estimate: OR 3.63 (95% CI 1.65-7.96)
Absolute Event Rate: 25.36% vs 8.03%
p-value: p=0.001
Background Left ventricular aneurysm (LVA) is a major mechanical complication following acute ST-segment elevation myocardial infarction (STEMI). This study aimed to evaluate the predictive ability of the lactate dehydrogenase to albumin ratio (LAR) for the risk of LVA among STEMI patients. Methods The study was conducted from July 2018 to 2025 across three medical centers in China. The study cohort comprised STEMI patients who underwent primary percutaneous coronary intervention across three medical centers. Multivariate logistic regression analysis and Restricted cubic spline plots were employed to assess the association between different LAR levels and LVA risk. Subgroup analyses were conducted to assess the consistency of the result. Results The study included 551, 471, and 1384 eligible participants from the first, second, and third cohort, respectively. After adjusting for potential confounders, individuals in the highest quartile of LAR (Q4) demonstrated a significantly elevated risk of developing LVA compared to those in the lowest quartile (Q1) across all cohorts (First cohort: OR = 3.63, 95% CI = 1.65 - 7.96, P = 0.001; Second cohort: OR = 6.01, 95% CI = 2.22 - 16.26, P 0.001; Third cohort: OR = 2.41, 95% CI = 1.47 - 3.96, P 0.001). RCS analysis revealed a positive linear association between LAR and the risk of LVA across the three cohorts (overall P 0.05). The predictive capacity of LAR for assessing LVA risk exceeded that of both lactate dehydrogenase and albumin (P 0.05). Subgroup analyses further reinforced the robustness of these findings. Conclusion An elevated LAR was independently associated with an increased risk of LVA development in patients with STEMI who underwent primary PCI.
Hu et al. (Wed,) conducted a cohort in Acute ST-segment elevation myocardial infarction (STEMI) (n=2,406). Highest quartile of lactate dehydrogenase-to-albumin ratio (LAR Q4) vs. Lowest quartile of lactate dehydrogenase-to-albumin ratio (LAR Q1) was evaluated on Left ventricular aneurysm (LVA) development (OR 3.63, 95% CI 1.65-7.96, p=0.001). An elevated lactate dehydrogenase-to-albumin ratio was independently associated with a significantly increased risk of left ventricular aneurysm development in STEMI patients undergoing primary PCI (OR 3.63).