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May 25, 2026Virulence0 citationsOpen Access

Effects of fecal microbiota transplantation and probiotics on the gut microbiome in antibiotic-treated septic patients: A pilot randomized controlled trial

YCYuanzhuo Chen JZJin Zhao JZJiangman Zhao

Key Points

This trial aims to evaluate the effects of fecal microbiota transplantation and probiotics on the gut microbiome of patients treated with antibiotics.
Pilot randomized controlled trial with septic patients receiving broad-spectrum antibiotics.
Evaluation of gut microbiome diversity and composition post-intervention.
Trial registered on ClinicalTrials.gov (NCT05578196).
FMT significantly restored gut microbiome diversity compared to probiotics (p=0.021).
Donor-recipient analysis indicated that FMT shifted microbiomes toward the donor enterotype.
FMT reduced pathogenic potential in critically ill sepsis patients.

Abstract

= 0.021). Donor-recipient analysis showed FMT shifted recipient microbiomes toward donor enterotype. This study provides preliminary evidence that FMT, but not the probiotic regimen, effectively restores gut microbiome diversity and composition, reduces pathogenic potential, and may improve clinical outcomes in critically ill sepsis patients after broad-spectrum antibiotics. This study was registered on ClinicalTrials.gov (NCT05578196).

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