What question did this study set out to answer?

The aim is to evaluate the impact of cytokine adsorption properties in CRRT filters on 30-day mortality.

May 25, 2026Blood Purification0 citations

The Impact of Continuous Renal Replacement Therapy Filters with Cytokine Adsorption Properties on Survival Outcomes: A Study Using Diagnosis Procedure Combination data

MHMasahiro Hyodo TYToshikazu Yogai RKRyota Kawai

Key Points

The aim is to evaluate the impact of cytokine adsorption properties in CRRT filters on 30-day mortality.
Analyzed data from the Diagnosis Procedure Combination database.
Focused on patients undergoing CRRT in ICU settings.
Categorized patients into AN69ST and non-AN69ST groups for comparison.
9,147 patients underwent CRRT with 1,419 in the AN69ST group.
The AN69ST group exhibited a significant reduction in 30-day mortality (HR 0.825, 95% CI 0.742-0.916).

Abstract

Background: Continuous renal replacement therapy (CRRT) is one of the adjunctive therapies for sepsis. This study compared 30-day mortality between conventional hemofilter and the polyethyleneimine-coated polyacrylonitrile membrane (AN69ST) in intensive care unit. Methods: Using the Diagnosis Procedure Combination (DPC) database provided by Medical Data Vision Co., Ltd. (MDV), our analysis focused on patients who underwent CRRT in ICU. The primary outcome was defined as the 30-day mortality rate. Patients were categorized into the AN69ST group and the non-AN69ST group. A subgroup analysis was performed. Furthermore, analysis was conducted considering changes in hemofilters to align with actual clinical practice. Results: A total of 9,147 patients underwent CRRT, including 1,419 in the AN69ST group. The analysis demonstrated a statistically significant reduction in 30-day mortality in the AN69ST group (hazard ratio (HR) 0.825, 95% confidence interval (CI) 0.742-0.916).

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