Osteoarthritis (OA) is a chronic degenerative joint disease involving both inflammatory dysregulation and calcium ion (Ca 2 ⁺) imbalance. To address these pathological features, a multifunctional nanocomposite— 1-CMCS–ATPMS@CP1@Sinomenine —was developed by integrating a Ca 2 ⁺-responsive MOF (CP1), a fluorescent small molecule (compound 1 ), a silicon-based linker (ATPMS), and biocompatible carboxymethyl chitosan (CMCS), with Sinomenine as the anti-inflammatory agent. The composite demonstrated excellent Ca 2 ⁺ selectivity, structural stability, and fluorescence responsiveness under physiological conditions. In an OA-like cell model induced by IL-1β, it effectively alleviated inflammation, showing superior performance to free Sinomenine. These results demonstrate the potential of 1-CMCS–ATPMS@CP1@Sinomenine as a dual-purpose platform for real-time Ca 2+ monitoring and targeted OA treatment.
Chen et al. (Sat,) studied this question.