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March 19, 2026Frontiers in Cardiovascular Medicine0 citationsOpen Access

Preoperative FluoroCT imaging -guided transapical closure of mitral paravalvular leak: a case report

QLQiong LuoYLYa LiHWHang Wu

Key Result

Preoperative FluoroCT imaging-guided transapical closure of a 5 mm posterior mitral paravalvular leak was successfully performed with no residual leak and a 1-hour procedure time.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P
Population
1 57-year-old female with prior double mechanical valve replacement (mitral and aortic) presenting with worsening exertional dyspnea and fatigue due to a 5 mm posterior mitral paravalvular leak.
I
Intervention
Preoperative FluoroCT imaging-guided transapical closure of mitral paravalvular leak using a 10 mm Ventricular Septal Defect occluder via left mini-thoracotomy.
O
Outcome
Procedural success (residual leak) and procedure time

Preoperative FluoroCT imaging planning successfully guided transapical closure of a posterior mitral paravalvular leak, enabling accurate localization and optimal fluoroscopic projection.

Limitations

  • Single case report
  • Requires validation in larger patient cohorts for reproducibility, safety, and long-term outcomes

Abstract

Background: Mitral paravalvular leak (PVL) is a recognized complication following prosthetic valve replacement, associated with heart failure, hemolysis, and increased morbidity. While redo surgery is the traditional treatment, transcatheter closure has emerged as a less invasive alternative, particularly in high-risk surgical candidates. Here, we present a case of preoperative FluoroCT imaging planning for transapical closure of mitral PVL. Case presentation: A 57-year-old female with prior double mechanical valve replacement (mitral and aortic) presented with worsening exertional dyspnea and fatigue.Transesophageal Echocardiography (TEE) identified a 5 mm posterior paravalvular leak adjacent to the mitral sewing ring. Preoperative contrast-enhanced CT analyzed with FluoroCT imaging software localized the leak to the 4-5 o'clock position and provided the optimal C-arm projection (cranial 48°, left anterior oblique 8°). Transapical closure via a left mini-thoracotomy was performed, and a 10 mm Ventricular Septal Defect occluder (Huayishengjie Medical Company, Beijing, China) was successfully deployed under TEE and fluoroscopic guidance. The patient had no residual leak, and total procedure time was 1 hour. Conclusions: FluroCT imaging-guided preoperative CT planning enables accurate localization of PVL and optimal fluoroscopic projection, reducing procedure time and improving safety. Transapical closure remains a feasible and effective approach for posterior mitral PVL in complex double-valve patients.

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Cite This Study

Luo et al. (2026) conducted a case report in Mitral paravalvular leak (n=1). Preoperative FluoroCT imaging-guided transapical closure was evaluated on Residual leak. Preoperative FluoroCT imaging-guided transapical closure of a 5 mm posterior mitral paravalvular leak was successfully performed with no residual leak and a 1-hour procedure time.

synapsesocial.com/papers/6a14e583cfc8ed0661c1ac94https://doi.org/10.3389/fcvm.2026.1764024
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