Association between neurodegenerative plasma biomarkers and geriatric depression in older adults with and without clinical dementia in Kinshasa, Democratic Republic of the Congo
Cross-sectional study explores biomarkers associated with geriatric depression in older adults with and without dementia, suggesting new insights for sub-Saharan Africa.
Key Points
This research aims to explore the link between neurodegenerative plasma biomarkers and geriatric depression among older adults in Kinshasa, particularly focusing on those with and without clinical dementia.
Conducted a cross-sectional study with 81 participants aged 65 and older.
Assessed dementia and depression using specific instruments, including the CSID and Geriatric Depression Scale.
Analyzed plasma biomarkers through logistic regression while adjusting for age, sex, and education.
80% of participants suspected of Alzheimer’s disease reported geriatric depression.
Cognitive scores were significantly lower in participants with dementia compared to those without.
GFAP and NfL biomarkers were associated with higher odds of depression (OR 1.98; p=0.02) and (OR 1.76; p=0.04), respectively.