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May 26, 2026Frontiers in Behavioral NeuroscienceOpen Access

Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction

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Authors

GJGergely JócsákDKDavid S. KissDADaiana Alymbaeva

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Overview

Randomized trial reveals how environmental endocrine disruptors impair cognitive and behavioral functions.

Key Points

  • This research investigates how endocrine disrupting chemicals (EDCs) affect cognitive and behavioral functions through synaptic mechanisms.
  • Integrative analysis of synaptic plasticity and neurotransmitter interactions in response to EDC exposure.
  • Examination of the impacts of various EDCs including bisphenols, phthalates, and heavy metals.
  • Assessment of functional outcomes related to long-term potentiation and behavioral changes.
  • EDC exposure led to significant cognitive impairments and behavioral abnormalities.
  • Documented alterations in glutamatergic transmission and calcium homeostasis disrupted synaptic functions.
  • Mitochondrial dysfunction and impaired blood–brain barrier integrity were observed, exacerbating neuropsychiatric risks.

Cite This Study

Jócsák et al. (2026) studied this question.

synapsesocial.com/papers/6a153790b5d9c58d83e8bfd4https://doi.org/10.3389/fnbeh.2026.1821381
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