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. Vitamin D supplementation also increased the likelihood of regression to normal glucose regulation. These findings are further supported by multiple aggregate-data meta-analyses showing a consistent benefit of vitamin D supplementation in adults with prediabetes. Compared with intensive lifestyle interventions, metformin, and incretin-based therapies, vitamin D is inexpensive, safe, accessible, and easy to implement, with an estimated number needed to treat of ∼30. The 2024 Endocrine Society Guideline now recommends vitamin D supplementation for adults with prediabetes at doses above the recommended dietary allowance without requiring routine 25(OH)D testing. Achieving and maintaining a blood 25(OH)D level above 40 ng/mL may confer additional benefit, but the hypothesis needs to be tested in clinical trials.
Amrein et al. (Mon,) studied this question.
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