From lipoprotein metabolism to blood clotting: Highlights of the 2025 Fredrickson lipid research conference

The biannual Fredrickson Lipid Research conference took place in person in Milwaukee, Wisconsin, from September 3-5, 2025. Each conference highlights the most advanced basic and translational research in lipids and lipoprotein metabolism. As with each Fredrickson Lipid Research conference, the overall theme is focused on "Lipid Metabolism, Lipoproteins, and Atherosclerosis," and this year included a special scientific session exploring the connections between Blood Clotting and Lipid Metabolism. This session underscored ongoing research aimed at explaining the mechanisms by which dyslipidemia alters the coagulation system and drives thrombotic cardiovascular disease. Other scientific session themes at the conference included Biomarkers in Cardiovascular Diseases, Efferocytosis and Inflammation, Regulation of Lipoproteins, Adipocyte Plasticity in Cardiometabolic Diseases, and Novel Therapeutic Strategies for Atherosclerosis. From the six moderated scientific sessions, invited speakers provided summaries of their work to showcase their contributions to the lipid and lipoprotein metabolism fields. This review article aims to serve as a resource for readers to learn more about ongoing research in lipid and lipoprotein metabolism and to encourage future studies and collaborations that advance the field.