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May 27, 2026Current Alzheimer Research

Mitochondrial Dysfunction in Alzheimer’s Disease: Beyond Energy Failure Toward a Pathogenic Nexus

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Authors

SSSrikruthi Kunigal SridharRajiv Gandhi University of Health SciencesPGPrakash GoudanavarRajiv Gandhi University of Health SciencesNNNimbagal Raghavendra NaveenRajiv Gandhi University of Health Sciences

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Overview

Review evaluates mitochondrial dysfunction impacts in Alzheimer’s disease, suggesting new therapeutic and diagnostic avenues.

Key Points

  • This review examines the role of mitochondrial dysfunction in Alzheimer’s disease and its implications for pathology and therapy.
  • Comprehensive literature evaluation across molecular, cellular, and systems-level studies.
  • Focus on bioenergetic collapse, redox imbalance, and mitochondrial dynamics.
  • Discussion of novel mechanisms like mitochondria-associated membranes and mitochondrial unfolded protein response.
  • Alzheimer’s disease exhibits mitochondrial abnormalities like impaired oxidative phosphorylation and increased reactive oxygen species (ROS).
  • Direct mitochondrial accumulation of amyloid-beta and tau affects protein import and respiratory chain function.
  • Therapeutic strategies include antioxidants and mitochondrial biomarkers for diagnosis and monitoring.

Cite This Study

Sridhar et al. (2026) studied this question.

synapsesocial.com/papers/6a1689ce0c924ddd1bd587f6https://doi.org/10.2174/0115672050433653251208201102
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