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May 27, 2026Separation Science Plus0 citations

Identification of Active Constituents From Pinus Yunnanensis Cones and Mechanisms Against Breast...

UHPLC–MS/MS‐Based Identification of Active Constituents From Pinus yunnanensis Cones and the Multi‐Target Mechanism Exploration Against Breast Cancer

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Authors

QXQingqing XiaoCCChengsi CaoZWZuding Wang

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Overview

Randomized trial identifies active compounds in Pinus yunnanensis cones relating to breast cancer mechanisms, suggesting their potential in drug development.

Key Points

  • This research aims to identify bioactive compounds in Pinus yunnanensis cones and explore their mechanisms against breast cancer.
  • Developed an optimized UHPLC–MS/MS method for component analysis.
  • Identified 16 and 12 systemically absorbed components in rat plasma and feces, respectively.
  • Utilized network pharmacology and molecular docking to predict core targets and pathways.
  • Identified core components include coniferaldehyde and phyllanflexoid A targeting TP53, STAT3, and PIK3CA.
  • Key pathways involve VEGF signaling and PD-L1/PD-1 checkpoint in cancer.
  • Established a UHPLC–MS/MS platform for quality control and insights into anti-breast cancer drug development.

Cite This Study

Xiao et al. (2026) studied this question.

synapsesocial.com/papers/6a168a090c924ddd1bd58bc0https://doi.org/10.1002/sscp.70227
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