Lactylation (Kla) is a novel post-translation protein modification regulation mechanism realized by the covalent coupling of lactate generated by glycolysis and lysine residues. Lactylation primarily includes histone Kla and non-histone Kla. Kla participates in biological processes in cells by regulating gene transcription and protein expression, as well as subcellular localization. Multiple organs are exposed to lactate metabolism disorder due to aging. Recent studies have demonstrated that Kla mediated by lactate metabolism disorder is involved in the occurrence and development of various age-related diseases. This article summarizes the functions of Kla in age-related diseases and the related mechanisms.
Li et al. (2026) studied this question.