Colorectal cancer (CRC) is a common malignant tumor, and its progression is closely related to the functional abnormalities of tumor suppressor genes. The p53 gene, as a key tumor suppressor gene, is mutated or deleted in about 50% of CRC cases, leading to the inactivation of p53 protein and accelerating tumorigenesis and metastasis. Current studies on p53 and CRC mostly focus on its overexpression and modification modes such as lactylation and methylation, while the research on p53 protein degradation and down-regulation mechanism is relatively scarce. This study takes p53 protein down-regulation as the core starting point, adopts literature research method and database retrieval method, combines public data mining with clinical sample verification, to explore the interaction mechanism between p53 down-regulation and related proteins such as HDAC. The results are expected to fill the knowledge gap of "p53 degradation regulating CRC invasion", improve the pathogenesis of CRC related to p53, and provide new scientific basis for precise diagnosis, prognostic stratification and targeted therapy target development of CRC.This study will provide new theoretical basis for molecular typing, prognostic evaluation and targeted therapy of early-stage CRC.
Zhao Jiasheng (2026) studied this question.