Synthesis of Benzo e 1,3oxazin-2-ones via the 4 + 2 Annulation between p -QMs and Carbamates

Key Points

• This study aims to develop an efficient method for synthesizing benzo[e][1,3]oxazin-2-ones using p-QMs and carbamates.
• Developed a [4 + 2] annulation strategy between p-QMs and carbamates
• Utilized mild reaction conditions
• Emphasized broad substrate scope and excellent yields.
• Achieved high yields of benzo[e][1,3]oxazin-2-ones under mild conditions
• Successfully demonstrated scalability of the synthesis
• Allowed for practical transformations of the synthesized compounds.