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May 27, 2026Chemical Communications0 citationsOpen Access

Inhibition of Mincle signaling by chemically synthesized disaccharide-type 6- O -acylated steryl β-glucosides (βASGs) and their analogues derived from plants

KYKenji YoshidaTMTakanori MatsumaruSYSho Yamasaki

Key Points

  • This research aims to investigate the inhibitory effects of chemically synthesized disaccharide βASGs on Mincle signaling.
  • Chemically synthesized disaccharide βASGs were derived from Dioscorea cayenensis.
  • Analogues were tested for their ability to block Mincle-mediated signaling.
  • The study focused on glycolipids with specific sterol and fatty acid moieties.
  • Disaccharide βASGs effectively block Mincle signaling, indicating potential therapeutic applications.
  • Inhibition is dependent on the structural components of glycolipids, particularly sterol and fatty acid parts.

Abstract

Chemically synthesized disaccharide βASGs from Dioscorea cayenensis and analogues effectively block Mincle-mediated signaling. This Mincle signaling inhibition requires a disaccharide backbone with sterol and fatty acid moieties, suggesting these glycolipids...

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Cite This Study

Yoshida et al. (2026) studied this question.

synapsesocial.com/papers/6a168b160c924ddd1bd59df8https://doi.org/10.1039/d6cc02089e
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Synthesis of plant-derived 6- O -acylated steryl β-glucosides (βASGs) and their derivatives: evaluation of Mincle-mediated signaling activity2026
  2. 2Systematic Evaluation of Regiochemistry and Lipidation of Aryl Trehalose Mincle Agonists2024 · 6 citations
  3. 3Identification of macrophage-inducible C-type lectin receptor stimulatory glycolipids from Lactiplantibacillus plantarum OLL2712 that induce interleukin-10 production in dendritic cells2026
  4. 4Preformed mincle dimers stabilized by an interchain disulfide bond in the neck region2024 · 4 citations
  5. 5The glycosylated root‐knot nematode effector Minc10750 suppresses plant immunity by destabilizing host chitinases2026