Rosa davurica Pall. extract significantly ameliorated isoproterenol-induced myocardial injury in vivo by reducing oxidative stress and suppressing inflammatory cytokines via the TNF-α pathway.
Does Rosa davurica Pall. extract ameliorate isoproterenol-induced acute myocardial ischemia in an in vivo model?
Rosa davurica Pall. extract demonstrates cardioprotective effects against acute myocardial ischemia in vivo by modulating the TNF-α signaling pathway and reducing oxidative stress.
Rosa davurica Pall. (RDP), a rosa fruit rich in bioactive compounds, has shown potential in alleviating cardiovascular diseases, yet its chemical composition and mechanisms against acute myocardial ischemia (AMI) remain unclear. This study comprehensively characterized 99 compounds in RDP extracts using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS), including flavonoids, terpenoids, and phenolic acids. By integrating transcriptomics and network pharmacology, we identified the tumor necrosis factor-alpha (TNF-α) signaling pathway as a key target in AMI progression. In vivo experiments demonstrated that RDP significantly ameliorated isoproterenol (ISO)-induced myocardial injury by reducing oxidative stress and suppressing the release of inflammatory cytokines (IL-6, IL-2, IL-17). Molecular docking and dynamics simulations further revealed that bioactive components in RDP, such as rutin and hyperoside, effectively bind to TNF-α and its receptor TNF receptor 1 (TNFR1), thereby modulating inflammatory responses. These findings provide valuable insights into the multi-target cardioprotective effects of RDP, supporting its application as a promising functional food.
yi et al. (Fri,) conducted a other in Acute myocardial ischemia. Rosa davurica Pall. (RDP) extract vs. Isoproterenol (ISO)-induced myocardial injury model was evaluated on Myocardial injury, oxidative stress, and inflammatory cytokine release. Rosa davurica Pall. extract significantly ameliorated isoproterenol-induced myocardial injury in vivo by reducing oxidative stress and suppressing inflammatory cytokines via the TNF-α pathway.