This paper establishes the cone-prism interlayer domain as the topological and ontological origin of the four-dimensional universe. Within the PFUSRC axiomatic system, the quasi-void interlayer between the 45° coaxial bicone and paired triangular pyramid is identified as the primary space for ζ-element (Zhiyuan, Wisdom Yuanzi) aggregation, order formation, and the emergence of the first growth cause. This paper proves that all cosmic and biological structures are passive shells; the true governing agency lies in ζ-elements within interstitial quasi-voids. A clear distinction is maintained between the global no first cause and the four-dimensional first cause, defined as the topological selection of a definite microgenesis (Weizhao) by ζ-element order inside the cone-prism interlayer. This framework provides universal isomorphic mapping from cosmic topology to biological growth, correcting the long-standing cognitive inversion: form mistaken for essence.
Zhenmin Wang (2026) studied this question.