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May 26, 2026Journal of Personalized MedicineOpen Access

Personalized SCD risk stratification in HCM guides ICD implantation via scores, advanced phenotyping, and patient preferences.

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Why the study?

Identifying patients with HCM who may benefit from primary prevention with an ICD remains challenging, as current European and American risk stratification strategies have limitations.

Design

Review

Key result

Personalized sudden cardiac death risk stratification in hypertrophic cardiomyopathy integrates conventional scores, advanced phenotyping, and patient preferences to guide ICD implantation.

Authors

JCJacopo CostantinoFBF BallatoreDPDaniele Porcelli

Discussion

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Overview

May guide individualized ICD decisions in HCM; leaves open prospective validation of integrated models.

Structured PICO

P
Population
Patients with Hypertrophic Cardiomyopathy (HCM)
I
Intervention
Sudden cardiac death risk stratification strategies (HCM Risk-SCD score, clinical risk markers, additional modifiers) and primary prevention with ICD

SCD risk stratification in HCM requires a personalized approach integrating conventional scores, advanced phenotyping, and shared decision-making.

Limitations

  • Current risk stratification strategies have limitations in accurately predicting arrhythmic events in a heterogeneous disease.
  • The HCM Risk-SCD score may fail to recognize some vulnerable individuals who remain below conventional treatment thresholds.

Cite This Study

Costantino et al. (2026) conducted a review in Hypertrophic Cardiomyopathy. Risk stratification strategies was evaluated. Personalized sudden cardiac death risk stratification in hypertrophic cardiomyopathy integrates conventional scores, advanced phenotyping, and patient preferences to guide ICD implantation.

synapsesocial.com/papers/6a16d2782fcf950e00055317https://doi.org/10.3390/jpm16060287
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